Dr. Patrick Gunning is a notable figure in the field of peptide science, specializing in the design and synthesis of therapeutic peptides. With over 20 years of experience, Dr. Gunning has played a crucial role in enhancing our understanding of peptide-based drug design, especially in targeting protein-protein interactions. His work not only underpins the scientific basis of peptide use in pharmaceutical applications but also sets the stage for potential advancements in drug development, particularly for treating cancer and inflammatory diseases.
Dr. Gunning has been instrumental in several groundbreaking studies, notably:
Dr. Gunning has been acknowledged with prestigious awards such as the E.W.R. Steacie Fellowship from the National Science and Engineering Research Council of Canada, underscoring his authoritative contributions to peptide research.
Dr. Helen M. Burt is a leading expert in the development and application of peptide-based delivery systems in medicine. Her pioneering work in the integration of peptides within drug delivery platforms is widely recognized as a critical advancement in pharmaceutical sciences. With a career spanning more than three decades, Dr. Burt has laid the groundwork for numerous innovations in targeted peptide delivery systems that improve therapeutic outcomes and patient safety.
Key publications by Dr. Burt include:
Dr. Burt’s influential research, characterized by its creativity and impact, has earned her numerous accolades, including the GSK Chair in Pharmaceutical Sciences at the University of British Columbia. Her work exemplifies the trustworthiness and expert knowledge she contributes to the peptide research community.
Ahrens, V. M., Bellmann-Sickert, K., & Beck-Sickinger, A. G. (2012a). Peptides and peptide conjugates: therapeutics on the upward path. Future Medicinal Chemistry, 4(12), 1567–1586. https://doi.org/10.4155/fmc.12.76
Ahrens, V. M., Bellmann-Sickert, K., & Beck-Sickinger, A. G. (2012b). Peptides and peptide conjugates: therapeutics on the upward path. Future Medicinal Chemistry, 4(12), 1567–1586. https://doi.org/10.4155/fmc.12.76
Amiche, M., Ladram, A., & Nicolas, P. (2008). A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. Peptides, 29(11), 2074–2082. https://doi.org/10.1016/j.peptides.2008.06.017
Chatterjee, J., Laufer, B., & Kessler, H. (2012). Synthesis of N-methylated cyclic peptides. Nature Protocols, 7(3), 432–444. https://doi.org/10.1038/nprot.2011.450
Erak, M., Bellmann-Sickert, K., Els-Heindl, S., & Beck-Sickinger, A. G. (2018). Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics. Bioorganic & Medicinal Chemistry, 26(10), 2759–2765. https://doi.org/10.1016/j.bmc.2018.01.012
Ermert, P., Luther, A., Zbinden, P., & Obrecht, D. (2019). Frontier between cyclic peptides and macrocycles. Methods in Molecular Biology, 147–202. https://doi.org/10.1007/978-1-4939-9504-2_9
Gentilucci, L., Tosi, P., Bauer, A., & De Marco, R. (2016). Modern tools for the chemical ligation and synthesis of modified peptides and proteins. Future Medicinal Chemistry, 8(18), 2287–2304. https://doi.org/10.4155/fmc-2016-0175
George, A. L., Foreman, R. E., Sayda, M. H., Reimann, F., Gribble, F. M., & Kay, R. G. (2023). Rapid and Quantitative Enrichment of Peptides from Plasma for Mass Spectrometric Analysis. Methods in Molecular Biology, 477–488. https://doi.org/10.1007/978-1-0716-2978-9_28
Goto, Y., & Suga, H. (2023). Ribosomal synthesis of peptides bearing noncanonical backbone structures via chemical posttranslational modifications. Methods in Molecular Biology, 255–266. https://doi.org/10.1007/978-1-0716-3214-7_13
Hansen, S., Arafiles, J. V. V., Ochtrop, P., & Hackenberger, C. P. R. (2022). Modular solid-phase synthesis of electrophilic cysteine-selective ethynyl-phosphonamidate peptides. Chemical Communications, 58(60), 8388–8391. https://doi.org/10.1039/d2cc02379b
Ilangala, A. B., Lechanteur, A., Fillet, M., & Piel, G. (2021). Therapeutic peptides for chemotherapy: Trends and challenges for advanced delivery systems. European Journal of Pharmaceutics and Biopharmaceutics, 167, 140–158. https://doi.org/10.1016/j.ejpb.2021.07.010
John, H., Walden, M., Sch�Fer, S., Genz, S., & Forssmann, W. (2004). Analytical procedures for quantification of peptides in pharmaceutical research by liquid chromatography?mass spectrometry. Analytical and Bioanalytical Chemistry, 378(4), 883–897. https://doi.org/10.1007/s00216-003-2298-y
Kabelka, I., & Vácha, R. (2021). Advances in molecular understanding of Α-Helical Membrane-Active peptides. Accounts of Chemical Research, 54(9), 2196–2204. https://doi.org/10.1021/acs.accounts.1c00047
Kobayashi, M., Fujita, K., Matsuda, K., & Wakimoto, T. (2023). Streamlined chemoenzymatic synthesis of cyclic peptides by non-ribosomal peptide cyclases. Journal of the American Chemical Society, 145(6), 3270–3275. https://doi.org/10.1021/jacs.2c11082
Kuhfeld, R. F., Eshpari, H., Atamer, Z., & Dallas, D. C. (2023). A comprehensive database of cheese-derived bitter peptides and correlation to their physical properties. Critical Reviews in Food Science and Nutrition, 1–15. https://doi.org/10.1080/10408398.2023.2220792
Meloni, B. P., Milani, D., Edwards, A. B., Anderton, R. S., Doig, R. L. O., Fitzgerald, M., Palmer, T. N., & Knuckey, N. W. (2015). Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties. Pharmacology & Therapeutics, 153, 36–54. https://doi.org/10.1016/j.pharmthera.2015.06.002
Moran, T. H. (2009). Gut peptides in the control of food intake. International Journal of Obesity, 33(S1), S7–S10. https://doi.org/10.1038/ijo.2009.9
Morra, G., Meli, M., & Colombo, G. (2008). Molecular dynamics Simulations of proteins and peptides: From folding to drug design. Current Protein and Peptide Science, 9(2), 181–196. https://doi.org/10.2174/138920308783955234
Moruz, L., & Käll, L. (2016). Peptide retention time prediction. Mass Spectrometry Reviews, 36(5), 615–623. https://doi.org/10.1002/mas.21488
Noble, J. E., Vila-Gómez, P., Rey, S., Dondi, C., Briones, A., Aggarwal, P., Hoose, A., Baran, M., & Ryadnov, M. G. (2023). Folding-Mediated DNA delivery by Α-Helical amphipathic peptides. ACS Biomaterials Science & Engineering, 9(5), 2584–2595. https://doi.org/10.1021/acsbiomaterials.3c00221
Sawada, T., Oyama, R., Tanaka, M., & Serizawa, T. (2020). Discovery of Surfactant-Like Peptides from a Phage-Displayed Peptide Library. Viruses, 12(12), 1442. https://doi.org/10.3390/v12121442
Tasdemiroglu, Y., Gourdie, R. G., & He, J. (2022). In vivo degradation forms, anti-degradation strategies, and clinical applications of therapeutic peptides in non-infectious chronic diseases. European Journal of Pharmacology, 932, 175192. https://doi.org/10.1016/j.ejphar.2022.175192
Van Regenmortel, M. (2001). Antigenicity and immunogenicity of synthetic peptides. Biologicals, 29(3–4), 209–213. https://doi.org/10.1006/biol.2001.0308
Wang, Q., Wang, F., Li, R., Wang, P., Yuan, R., Liu, D., Liu, Y., Luan, Y., Wang, C., & Dong, S. (2023). Fine tuning the properties of stapled peptides by stereogenic Α‐Amino acid bridges. Chemistry – a European Journal, 29(29). https://doi.org/10.1002/chem.202203624
Yuan, Y. (2020). Mechanisms inspired targeting peptides. Advances in Experimental Medicine and Biology, 531–546. https://doi.org/10.1007/978-981-15-3266-5_21
