Core Benefits

Metabolic Regulation

Promotes Lipid Metabolism: Activating REV-ERB receptors enhances lipid oxidation, increasing the body's efficiency in using fat for energy.

Enhances Mitochondrial Function: Significantly increases the activity and number of cellular energy factories (mitochondria), increasing ATP production.

Improves Metabolic Flexibility: Helps the body switch more efficiently between carbohydrates and fat for energy, contributing to stable blood sugar.

 Circadian Rhythm Regulation

Regulates circadian rhythms: Influences the expression of genes related to the sleep-wake cycle, helping to maintain a healthy circadian rhythm.

Possibly Improves Jet Lag: Potentially reduces discomfort from cross-time zone travel by regulating core circadian clock proteins.

Potential Research Applications

Obesity Research: Shows potential to reduce fat mass while maintaining muscle mass in animal models.

Mechanism of Action: Valuable for improving metabolic problems such as insulin sensitivity, dyslipidemia, and hypertension.

Mitochondrial Disease Research: Significant for exploring treatments related to enhancing mitochondrial function.

Mechanism of Action: SLU-PP-322 selectively binds to and activates REV-ERBα and REV-ERBβ. Nuclear receptors play a crucial role; these receptors are transcription factors that regulate the expression of a variety of genes:

Promoting the expression of genes involved in lipid oxidation

Enhancing the expression of genes related to mitochondrial biosynthesis

Regulating key pathways related to energy metabolism and the circadian rhythm